Beilstein J. Org. Chem.2013,9, 1652–1662, doi:10.3762/bjoc.9.189
polycationic system was synthesized via copolymerization of N,N-diethylacrylamide (DEAAm) and 2-(dimethylamino)ethylmethacrylate (DMAEMA). N,N’-bis(4-chlorobutanoyl)cystamine was used as disulfide-containing cross-linker to form networks by the quaternization of tertiary amine groups. The insoluble cationic
transition temperature (Tg), swelling behavior and cloud points (Tc) were investigated. Redox-responsive behavior was further analyzed by rheological measurements.
Keywords: cationic hydrogel; cross-linked polymer; 2-(dimethylamino)ethylmethacrylate (DMAEMA); disulfide cleavage; N,N-diethylacrylamide
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Graphical Abstract
Scheme 1:
(a) Synthesis of a polycationic cross-linked hydrogel containing disulfide groups. (b) Reductive cl...